Processing of Mammalian and PlantS-Adenosylmethionine Decarboxylase Proenzymes
نویسندگان
چکیده
منابع مشابه
S - Adenosylmethionine decarboxylase Anthony
S-Adenosylmethionine decarboxylase is a key enzyme for the synthesis of polyamines in mammals, plants and many other species that use aminopropyltransferases for this pathway. It catalyses the formation of S-adenosyl-1(methyl th io)-3-propylamine (decarboxyla ted S-adenosylmethionine), which is used as the aminopropyl donor. This is the sole function of decarboxylated S-adenosylmethionine. Its ...
متن کاملOrnithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids.
The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (...
متن کاملS-adenosylmethionine decarboxylase of corn seedlings.
S-Adenosylmethionine decarboxylase (EC 4.1.1.50) has been purified 500-fold in 30% yield from the extract of etiolated corn seedlings (cv. Golden Crossbantam Bell). This preparation had a molecular weight of approximately 25,000. The K(m) value was 5 micromolar for S-adenosylmethionine. Methylglyoxal bis(guanylhydrazone), hydroxylamine, and sulfhydryl reagents (such as p-hydroxymercuriphenylsul...
متن کاملFeedback regulation of S-adenosylmethionine decarboxylase synthesis.
Treatment of Ehrlich ascites-tumour cells with 1-amino-oxy-3-aminopropane (AOAP), a potent inhibitor of ornithine decarboxylase, resulted in a marked decrease in cellular contents of putrescine and spermidine, concomitant with an arrest of cell growth. The activity of S-adenosylmethionine decarboxylase (AdoMetDC) was greatly increased in cells treated with AOAP. This increase in AdoMetDC activi...
متن کاملInhibition of Mammalian S-Adenosylmethionine Decarboxylase Activity by l,l’-[(Methylethanediylidene)- dinitrilo]bis(3=aminoguanidine)*
Inactivation of rat S-adenosylmethionine decarboxylase by l,l’-[(methylethanediylidene)dinitrilolbis(3-aminoguanidine) was studied both in vitro and in vivo. When incubated with the purified rat liver enzyme in the presence of putrestine this compound was a potent irreversible inhibitor. Inactivation proceeded as a first order reaction, which varied with the concentration of drug added but show...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.45.28342